Techniques of orthomolecular diagnosis.
نویسندگان
چکیده
We believe that a significant improvement in health and a decrease in the age-specific morbidity and mortality from various diseases can be achieved by varying the concentrations in the body of the molecules that are normally present, many of which are required for life (1). The corresponding field is described as “orthomolecular medicine.” An important part of orthomolecular medicine, orthomolecular diagnosis, is the process of determining the concentrations of various substances in the human body (2). We have studied some of the techniques for determining the amounts of different substances in body fluids. Most of our experiments on orthomolecular diagnosis have involved the use of gas-liquid chromatography, ion-exchange chromatography, or mass spectrometry. In this paper we discuss the approach to this problem that we have developed during the past five years and discuss examples taken from the chromatographic experiments. In general, we have not required that our experiments be based on any particular biochemical mechanisms related to particular diseases. We have not actively searched for qualitative or quantitative changes in single substances that are characteristic of single diseases. Instead, for each disease we have carried out careful quantitative analysis for as many substances as we are able to measure at low cost. We are particularly interested in preventive medicine. Therefore, we have restricted these measurements in the effort to achieve the goal that the entire procedure can be offered to apparently well persons at a cost of $10 or less if it is found to be useful.
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 20 8 شماره
صفحات -
تاریخ انتشار 1974